Drug Discovery & Development

Drug discovery is the procedure by which new candidate drugs are found. Truly, drugs were found through distinguishing the dynamic ingredient from traditional remedies or by fortunate revelation. Later chemical libraries of engineered small molecules, natural products or extracts were screened in intact cells or whole organisms to recognize substances that have an alluring helpful impact in a procedure known as classical pharmacology. Present day drug discovery includes the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability.

Drug development is the way toward conveying another pharmaceutical drug to the market once a lead compound has been recognized through the procedure of drug discovery. It incorporates preclinical research on microorganisms and animals, filing for regulatory status for an investigational new drug to initiate clinical trials on humans, and may include the step of obtaining regulatory approval with a new drug application to market the drug.

  • Stages of drug discovery, development, and clinical evaluation
  • Strategies for identifying key drug discovery targets
  • Screening strategies for discovering and characterizing small molecule modulators
  • Use of structure-based drug design to develop structure-activity relationships

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